Topiramate is used with other medications to treat certain types of seizures in patients with epilepsy or Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is used to treat patients who continue to have seizures even when they take other anti-seizure medications. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain. Topiramate is also sometimes used to treat cluster headaches and infantile spasms (a condition that causes uncontrolled stiffening of the body in babies).