Cetirizine hydrochloride, an anti histamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist used in the treatment of allergies, hay fever, angioedema, and urticaria. Cetirizine is an effective agent in the treatment of Kimura's disease, which mostly occurs in young Asian men, affecting the lymph nodes and soft tissue of the head and neck in the form of tumor-like lesions. Cetirizine's properties of being effective both in the treatment of pruritus> and as an anti-inflammatory agent make it suitable for the treatment of the pruritus associated with these lesions.